Urticarial Vasculitis Treatment

Urticarial Vasculitis Treatment – How Do You Treat Urticarial Vasculitis?

Depending on the cause of urticarial vasculitis, it can be quickly treated and resolved by itself. That is, normocomplementaemic urticarial vasculitis is more easily treated and quicker to heal.

However, if the cause is due to systemic processes like autoimmune diseases, then the condition can be controlled by medication and other means but the condition lasts for a longer time period. Hypocomplentemia urticarial vasculitis tends to have this feature.

Identification and avoidance of triggers

With any skin condition, it is important to first identify and avoid triggers that can set off urticarial vasculitis or wheals on the skin. For instance, non-steroidal anti-inflammatory drugs (NSAID), penicillin and ACE inhibitors can trigger urticarial vasculitis. Hence, the urticarial vasculitis treatment is to avoid taking these medications which bring on symptoms.

Also, certain foods and drinks can trigger these symptoms.

Hence, it is important to identify the triggers of this condition. Identification and avoidance of triggers can be recognised and classified by your dermatologist (skin specialist), rheumatologist (joint specialist) or immunologist (allergy or immune specialist). They will perform specific diagnostic test to help identify your triggers.

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Avoid Exacerbation of Symptoms

People with urticarial vasculitis should be advised to avoid factors that increase or exacerbate existing symptoms. For instance, increased pressure around the skin can cause an increase in vasculitis and scarring and hence worsening symptoms. This can easily be avoided by following simple steps to stop exacerbation. Here are some simple tips to reduce symptoms:

  • Prevent local pressure at sites of wheals or any red areas
  • Avoid wearing tight fitting clothes
  • Warmth or heat can increase itching and hence symptoms, hence avoid warm unventilated environments
  • Keep yourself cool
  • Avoid itching


Antihistamines are medications that stop allergic reactions that can cause redness, inflammation and increased blood flow. Antihistamines work by blocking H1 receptors that inhibit histamine and hence stop redness and inflammation.

Antihistamines are useful for urticarial vasculitis treatment and management as it stops wheals from appearing on the skin and reduce irritation. It also helps reduce the itchiness, swelling and inflammation.

One of the common histamine medication used in urticarial vasculitis is Hydroxyzine, Cetirizine and Diphenhydramine. These medications are also high effective in reducing irritation and symptoms.

Non-steroidal anti-inflammatory drugs (NSAIDs)

Even though in some people, NSAIDs can trigger urticarial vasculitis, for people who aren’t affected by NSAID, it can reduce the inflammation and symptoms in the skin. One of the most used NSAID is Indocid which is fast acting and significantly helps to reduce inflammation and pain. NSAID is best prescribed by your specialist for effectiveness.


Corticosteroids are a powerful anti-inflammatory that will help reduce vasculitis. It will also significantly help reduce wheals, redness and pain. Corticosteroids can be taken orally or topically (applied on the skin). It can also be injected if severe.

Corticosteroids (such as prednisone) are used for long term management for urticarial vasculitis treatment as it helps control and manage the severity of symptoms.

One of the big issues or side effects of corticosteroids is that it can cause skin thinning, bruising, skin tears and blemishes on your skin. Hence, proper medical management by your doctor is necessary to avoid these issues.


Antimalarials are known for their anti-inflammatory properties especially in skin conditions. They help reduce the appearance of wheals and pain. Hydroxychloroquine or Plaquenil is one of the most effective and most commonly prescribed anti-malarial medications.

Immunosuppressive treatment

With people who have urticarial vasculitis caused by autoimmune diseases like SLE, immunosuppressive medication will help reduce symptoms. One of the most common medication used is Cyclosporin A which is an immunosuppressive medication. Careful administration and management of these medication is important as they can be dangerous and should be prescribed from a specialist.